Novel Titanium Implant: A 3D Multifunction Architecture with Charge‐Trapping and Piezoelectric Self‐Stimulation. Issue 11 (18th January 2023)

• Record Type: Journal Article
• Authors: Sun, Lei; Chen, Xuzhuo; Ma, Kun; Chen, Ruiguo; Mao, Yi; Chao, Rui; Wang, Hui; Yu, Bin; Wang, Junfeng; Zhang, Shanyong
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 11(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-18
• Subjects: anti‐inflammatory materials -- bone osseointegration -- charge‐trapping antibacterials -- piezoelectric self‐stimulation -- titanium implants; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202620
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Implant‐associated infection and inflammation are the main causes of implant failure, causing irreversible damage and significantly increasing clinical risks and economic losses. In this study, a 3D multifunctional architecture is constructed that consisted of hierarchical TiO2 nanotubes (NTs) and electrospun polyvinylidene fluoride nanofiber layers on the surface of a titanium implant. The movement of bacteria through the nanofiber layer is facilitated by its appropriate pore sizes and electrostatic interactions to reach the NT layer where the bacteria are killed by positive charge traps. In contrast, the macrophages tend to adhere to the nanofiber layer. The mechanical interactions between the macrophages and piezoelectric nanofibers generate a self‐stimulated electric field that regulated an anti‐inflammatory phenotype. This study provides a new method for multifunctional implant materials with antibacterial, piezoelectrically self‐stimulated anti‐inflammatory, and osteointegration properties that are driven by electrical stimulation. Abstract : A 3D multifunctional architecture is constructed that consisted of hierarchical titanium dioxide nanotube and electrospun polyvinylidene fluoride nanofiber layers on the surface of the titanium implants. The antibacterial, anti‐inflammatory, and osteogenic properties are remarkably enhanced both in vitro and in vivo, providing a prospective approach of the electrically driven multifunctionalization for implants.