Double HCG trigger improves recovery of oocytes in women with a paucifollicular response to ovarian stimulation: A pilot study. Issue 1 (7th June 2021)

• Record Type: Journal Article
• Authors: Tesarik, Jan; Galán‐Lázaro, Maribel; Mendoza, Nicolas; Mendoza‐Tesarik, Raquel
• Is Part Of: International journal of gynaecology and obstetrics. Volume 157:Issue 1(2022)
• Page Start: 149
• Page End: 153
• Publication Date: 2021-06-07
• Subjects: double HCG trigger -- empty follicle syndrome -- older women -- paucifollicular ovarian response -- poor responders -- virtual sonographic folliculoscopy; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.13735
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To examine whether adding a second HCG trigger, 12.5 h after the first (36.5 h before ovarian puncture), can facilitate recovery of oocytes in women with a paucifollicular response to ovarian stimulation. Methods: A total of 85 women aged 35–42 years, with a paucifollicular response to ovarian stimulation and who had experienced a total failure of oocyte recovery after the standard HCG ovulation trigger 36.5 h before ovarian puncture, were subsequently treated by the same protocol but with the addition of a second HCG trigger 12.5 h later. The recovered oocytes were inseminated by intracytoplasmic sperm injection (ICSI) and all available embryos were transferred 3 days later. Results: The double trigger enabled recovery of cumulus oophorus cells from most of the follicles in the women who experienced failure of total recovery of oocytes after a single trigger. Fifteen patients became pregnant, and no signs of ovarian hyperstimulation syndrome were observed. Nine women delivered a healthy child. Conclusion: In women aged 35–42 years with a paucifollicular response to ovarian stimulation, a double HCG trigger appears to improve the rate of oocyte recovery. The conclusion of this pilot study needs to be confirmed by larger prospective trials. Abstract : A second HCG injection, 12.5 h after the first and 24 h before follicle aspiration, improves recovery of oocytes from women with poor ovarian reserve.