Self-Tuning Insulin Adjustment Algorithm for Type 1 Diabetic Patients based on Multi-Doses Regime. Issue 2 (8th July 2010)

• Record Type: Journal Article
• Authors: Campos-Delgado, D. U.; Femat, R.; Hernández-Ordoñez, M.; Gordillo-Moscoso, A.
• Is Part Of: Applied bionics and biomechanics. Volume 2:Issue 2(2005)
• Page Start: 61
• Page End: 71
• Publication Date: 2010-07-08
• Subjects: Diabetes -- self-tuning algorithm -- multi-doses regime -- insulin adjustment; Bionics -- Periodicals; Biomechanics -- Periodicals; Biomedical engineering -- Periodicals; 003.505
• DOI: 10.1533/abbi.2004.0031
• Languages: English
• ISSNs: 1176-2322

Abstract

Abstract : A self-tuning algorithm is presented for on-line insulin dosage adjustment in type 1 diabetic patients (chronic stage). The algorithm suggested does not need information of the patient insulin–glucose dynamics (model-free). Three doses are programmed daily, where a combination of two types of insulin: rapid/short and intermediate/long acting is injected into the patient through a subcutaneous route. The doses adaptation is performed by reducing the error in the blood glucose level from euglycemics. In this way, a total of five doses are tuned per day: three rapid/short and two intermediate/long, where there is large penalty to avoid hypoglycemic scenarios. Closed-loop simulation results are illustrated using a detailed nonlinear model of the subcutaneous insulin–glucose dynamics in a type 1 diabetic patient with meal intake.