Connectivity and Excitability Shape Seizure Circuits. Issue 3 (May 2023)

• Record Type: Journal Article
• Authors: Brodovskaya, Anastasia; Kapur, Jaideep
• Is Part Of: Epilepsy currents. Volume 23:Issue 3(2023)
• Page Start: 169
• Page End: 174
• Publication Date: 2023-05
• Subjects: generalized tonic–clonic seizures -- circuit mapping -- anatomic connectivity -- neuronal excitability -- basal ganglia -- bilateral synchrony -- superficial cortical layers 2/3 -- motor cortex; Epilepsy -- Periodicals; 616.853005
• DOI: 10.1177/15357597221136961
• Languages: English
• ISSNs: 1535-7597

Abstract

Mapping neuronal circuits that generate focal to bilateral tonic–clonic seizures is essential for understanding general principles of seizure propagation and modifying the risk of death and injury due to bilateral motor seizures. We used novel techniques developed over the past decade to study these circuits. We propose the general hypothesis that at the mesoscale, seizures follow anatomical projections of the seizure focus, preferentially activating more excitable neurons.