High amplitude propagated contractions with Glycerin versus Bisacodyl: A within‐subject comparison in children undergoing colonic manometry. Issue 5 (27th February 2023)

• Record Type: Journal Article
• Authors: Mansi, Sherief; Bahia, Gracielle; Patel, Dhiren; Dorfman, Lev; El‐Chammas, Khalil; Fei, Lin; Liu, Chunyan; Santucci, Neha R.; Graham, Kahleb; Kaul, Ajay
• Is Part Of: Neurogastroenterology & motility. Volume 35:Issue 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-27
• Subjects: Bisacodyl -- children -- colonic manometry -- constipation -- fecal incontinence -- Glycerin -- high amplitude propagated contractions; Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.14544
• Languages: English
• ISSNs: 1350-1925

Abstract

Abstract: Background: The presence of high amplitude propagated contractions (HAPCs) measured by colonic manometry (CM) reflect an intact neuromuscular function of the colon. Bisacodyl and Glycerin are colonic stimulants that induce HAPCs and are used for the treatment of constipation. HAPCs characteristics with each drug have not been compared before. We aimed to compare the HAPC characteristics with Bisacodyl and Glycerin in children undergoing CM for constipation. Methods: This is a prospective single‐center cross‐over study of children aged 2–18 years undergoing CM. All patients received both Glycerin and Bisacodyl during CM. They were randomized to group A with Bisacodyl first ( n = 22) and group B with Glycerin first ( n = 23), with 1.5 hours in between each dose. Differences in patient and HAPC characteristics between groups were summarized using descriptive statistics and compared using Chi‐square test or Wilcoxon rank sum test as appropriate. Key Results: A total of 45 patients were included. HAPCs post Bisacodyl had a longer duration of action (median of 40 vs 21.5 min, p < 0.0001), longer propagation (median of 70 vs 60 cm, p = 0.02), and more HAPCs (median of 10 vs 5, p < 0.0001) compared Glycerin. No differences were found in the HAPC amplitude and onset of action between both medications. Abstract : Bisacodyl is more effective than Glycerin as a colonic stimulant in inducing HAPCs potentially making it more effective in the treatment of constipation and fecal incontinence with enemas.