Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease. Issue 8 (14th April 2023)

• Record Type: Journal Article
• Authors: Baaten, Constance C.F.M.J.; Vondenhoff, Sonja; Noels, Heidi
• Is Part Of: Circulation research. Volume 132:Issue 8(2023)
• Page Start: 970
• Page End: 992
• Publication Date: 2023-04-14
• Subjects: atherosclerosis -- cardiovascular diseases -- chronic kidney diseases -- endothelial cells -- vascular stiffness; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.123.321752
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due to the proinflammatory, prothrombotic and uremic environment caused by the decline in kidney function, adding to the increase in cardiovascular complications in this vulnerable patient population. In this review, we discuss endothelial cell functioning in healthy conditions and the contribution of endothelial cell dysfunction to cardiovascular disease. Further, we summarize the phenotypic changes of the endothelium in chronic kidney disease patients and the relation of endothelial cell dysfunction to cardiovascular risk in chronic kidney disease. We also review the mechanisms that underlie endothelial changes in chronic kidney disease and consider potential pharmacological interventions that can ameliorate endothelial health.