Topological network measures for drug repositioning. Issue 4 (22nd December 2020)

• Record Type: Journal Article
• Authors: Badkas, Apurva; De Landtsheer, Sébastien; Sauter, Thomas
• Is Part Of: Briefings in bioinformatics. Volume 22:Issue 4(2021)
• Publication Date: 2020-12-22
• Subjects: drug repositioning -- networks -- topological network measures -- topology -- computational methods; Genetics -- Data processing -- Periodicals; Molecular biology -- Data processing -- Periodicals; Genomes -- Data processing -- Periodicals; 572.80285
• DOI: 10.1093/bib/bbaa357
• Languages: English
• ISSNs: 1467-5463

Abstract

Abstract: Drug repositioning has received increased attention since the past decade as several blockbuster drugs have come out of repositioning. Computational approaches are significantly contributing to these efforts, of which, network-based methods play a key role. Various structural (topological) network measures have thereby contributed to uncovering unintuitive functional relationships and repositioning candidates in drug-disease and other networks. This review gives a broad overview of the topic, and offers perspectives on the application of topological measures for network analysis. It also discusses unexplored measures, and draws attention to a wider scope of application efforts, especially in drug repositioning.