Urinary magnesium predicts risk of cardiovascular disease in Chronic Kidney Disease stage 1–4 patients. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Yuan, Qiongjing; Xie, Yanyun; Peng, Zhangzhe; Wang, Jinwei; Zhou, Qiaoling; Xiao, Xiangcheng; Wang, Wei; Huang, Ling; Tang, Wenbin; Li, Xiaozhao; Zhang, Luxia; Wang, Fang; Zhao, Ming-Hui; Tao, Lijian; He, Kevin; Wanggou, Siyi; Xu, Hui; Zhao, Ming-Hui; Zhang, Luxia; Wang, Xiaoqin; Yuan, Jun; Zhou, Qiaoling; Yuan, Qiongjing; Chen, Menghua; Zhou, Xiaoling; Fu, Shuxia; Li, Shaomei; Zha, Yan; Huang, Rongsai; Liu, Zhangsuo; Zhang, JunJun; Wang, Li; Pu, Lei; Liu, Jian; Li, Suhua; Xiong, Zuying; Liang, Wei; Zhao, Jinghong; Mu, Jiao; Lian, Xiyan; Liao, Yunjuan; Gan, Hua; Liao, Liping; Wang, Rong; Lv, Zhimei; Liao, Yunhua; Pan, Ling; Yang, Xiaoping; Lin, Zhifeng; Tong, Zongwu; Zhu, Yun; He, Qiang; Wu, Fuquan; Li, Rong; Rong, Kai; Wang, Caili; Zhang, Yanhui; Wang, Yue; Tang, Wen; Wu, Hua; Zhao, Ban; Li, Rongshan; Wang, Lihua; Li, Detian; Du, Feng; Wu, Yonggui; Zhang, Wei; Lin, Shan; Xu, Pengcheng; Lin, Hongli; Hu, Zhao; Pei, Fei; Zhang, Haisong; Gao, Yan; Sun, Luying; Li, Xia; Wang, Wenke; Lv, Fengling; Wang, Deguang; Wang, Xuerong; Xu, Dongmei; Tang, Lijun; Ma, Yingchun; Wang, Tingting; Fu, Ping; Wang, Tingli; Xing, Changying; Zhang, Chengning; Xu, Xudong; He, Haidong; Liao, Xiaohui; Xie, Shuqin; Hu, Guicai; Huang, Lan;
• Is Part Of: Clinical nutrition. Volume 40:Issue 4(2021)
• Page Start: 2394
• Page End: 2400
• Publication Date: 2021-04
• Subjects: 24 h Urinary magnesium concentration (24 h UMg) -- Cardiovascular disease (CVD) -- Chronic kidney disease (CKD) -- End-stage renal disease (ESRD); Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2020.10.036
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Observational studies on dietary or circulating magnesium and risk of cardiovascular disease (CVD) in Chronic Kidney Disease (CKD) stage 1–4 have reported no-to-modest inverse associations. 24 h Urinary magnesium concentration (24 h UMg), an indicator of intestinal magnesium absorption, may provide better insight into the connection of CKD progression. We examined 3179 participants aged 18–74 years with CKD stage 1–4 in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) study, a prospective population-based cohort study. Data were analysed using Spearman rank-order correlation coefficients for all comparisons. We also performed a time-to-event analysis of the data using the Kaplan–Meier survival model, Cox proportional hazard model and competing risk Fine and Gray subdistribution hazard model. During a median follow-up of 4.19 years (interquartile range, 3.43–5.09 years), when modelling end-stage renal disease (ESRD), CVD and death, 24 h UMg was associated with risk of CVD (HR, 1.612 (95% CI, 1.056–2.460)), while no significant association with ESRD and death endpoints could be detected. 24 h UMg risk variants display a modest association with CVD in CKD stage 1–4 patients. Trial registration: ClinicalTrials.gov Identifier NCT03041987. Registered January 1, 2012. (retrospectively registered) (https://www.clinicaltrials.gov/ct2/show/NCT03041987?term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1 ). Highlights: 24 h UMg variants display a modest association with cardiovascular disease in CKD stage 1-4 patients. 24 h UMg variants are not related to end-stage renal disease (ESRD) in CKD stage 1–4 patients. 24 h UMg variants have no association with mortality in CKD stage 1–4 patients.