5‐Substituted 1, 2, 4‐Triazole‐3‐Carboxylates and 5‐Substituted Ribavirin Analogs Synthesis. Issue 11 (8th November 2021)

• Record Type: Journal Article
• Authors: Matveev, Andrey V.; Grebenkina, Lyubov E.; Prutkov, Alexander N.; Chudinov, Mikhail V.
• Is Part Of: Current protocols. Volume 1:Issue 11(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-08
• Subjects: ribavirin analogs -- nucleoside analogs -- 5‐substituted ethyl 1, 2, 4‐triazole‐3‐carboxylates; Life sciences -- Laboratory manuals -- Periodicals; Biology -- Laboratory manuals -- Periodicals; Life sciences -- Technique -- Periodicals; Biology -- Technique -- Periodicals; 570.028
• DOI: 10.1002/cpz1.281
• Languages: English
• ISSNs: 2691-1299

Abstract

Abstract: Ribavirin analogs substituted at position 5 of the heterocyclic base are interesting for their biological activity. This protocol describes a synthetic route to several such ribavirin analogs with a wide range of substituents.© 2021 Wiley Periodicals LLC. Basic Protocol 1 : Synthesis and purification of 5‐substituted ethyl 1, 2, 4‐triazole‐3‐carboxylates – synthetic precursors of nucleobases Basic Protocol 2 : Synthesis and purification of protected 1, 2, 4‐triazole nucleoside analogs Basic Protocol 3 : Synthesis and purification of 5‐substituted ribavirin analogs