Kinetic Controlled Chirality Transfer and Induction in 2D Hydrogen‐Bonding Assemblies of Glycylglycine on Au(111). Issue 17 (4th January 2023) - Zhang, Xin
Abstract: Chirality transfer is of vital importance that dominates the structure and functionality of biological systems and living matters. External physical stimulations, e.g. polarized light and mechanical forces, can trigger the chirality symmetry breaking, leading to the appearance of the enantiomeric entities created from a chiral self‐assembly of achiral molecule. Here, several 2D assemblies with different chirality, synthesized on Au(111) surface by using achiral building blocks – glycylglycine (digly), the simplest polypeptide are reported. By delicately tuning the kinetic factors, i.e., one‐step slow/rapid deposition, or stepwise slow deposition with mild annealing, achiral square hydrogen‐bond organic frameworks (HOF), homochiral rhombic HOF and racemic rectangular assembly are achieved, respectively. Chirality induction and related symmetry broken in assemblies are introduced by the handedness (H‐bond configurations in principle) of the assembled motifs and then amplified to the entire assemblies via the interaction between motifs. The results show that the chirality transfer and induction of biological assemblies can be tuned by altering the kinetic factors instead of applying external forces, which may offer an in‐depth understanding and practical approach to peptide chiral assembly on the surfaces and can further facilitate the design of desired complex biomolecular superstructures. Abstract : 2D assemblies with different chirality, e.g. achiral square hydrogen‐bond organic frameworks (HOF), homochiral rhombic HOF, and racemic assembly, are synthesized on Au(111) surface by using achiral glycylglycine molecule. By delicately tuning kinetic factors, chirality induction and related symmetry broken in assemblies are introduced from the handedness of the assembled motifs and then amplified to the entire assemblies.