Clinical significance of interleukin-18 for the diagnosis and prediction of disease course in systemic juvenile idiopathic arthritis. (17th November 2020)

• Record Type: Journal Article
• Authors: Mizuta, Mao; Shimizu, Masaki; Inoue, Natsumi; Ikawa, Yasuhiro; Nakagishi, Yasuo; Yasuoka, Ryuhei; Iwata, Naomi; Yachie, Akihiro
• Is Part Of: Rheumatology. Volume 60:Number 5(2021)
• Page Start: 2421
• Page End: 2426
• Publication Date: 2020-11-17
• Subjects: interleukin-18 -- systemic juvenile idiopathic arthritis -- diagnosis -- remission; Rheumatism -- Periodicals; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1093/rheumatology/keaa634
• Languages: English
• ISSNs: 1462-0324

Abstract

Abstract: Objective: To investigate the clinical significance of serum IL-18 levels for the diagnosis of systemic JIA (s-JIA) and to predict the disease course of s-JIA. Methods: Overall, 116 patients with s-JIA, 151 with other diseases and 20 healthy controls were analysed. Serum IL-18 levels were measured longitudinally in 41 patients with s-JIA from active phase through remission phase. Serum IL-18 levels were quantified via enzyme-linked immunosorbent assay and the results were compared with clinical features and the disease course of s-JIA. Results: The serum IL-18 level cut-off value for differentiation of s-JIA from other diseases was 4800 pg/ml. In patients with a monocyclic course, serum IL-18 levels steadily decreased during the inactive phase and low levels were sustained during remission. In contrast, in patients with a chronic course, elevated serum IL-18 levels were sustained even during the inactive phase. In patients with a polycyclic course, serum IL-18 levels were elevated during disease flares and normalized during the inactive phase. The serum IL-18 level cut-off value for diagnosis of remission in s-JIA was 595 pg/ml, Conclusion: Serum IL-18 levels of >4800 pg/ml may be useful for differentiating between s-JIA and other diseases. Monitoring of serum IL-18 levels might be useful for predicting the disease course and assessing remission in s-JIA.