Mistimed malaria parasites re‐synchronize with host feeding‐fasting rhythms by shortening the duration of intra‐erythrocytic development. (22nd November 2021)

• Record Type: Journal Article
• Authors: O'Donnell, Aidan J.; Greischar, Megan A.; Reece, Sarah E.
• Other Names: Else Kathryn guestEditor.; Gibbs Julie guestEditor.
• Is Part Of: Parasite immunology. Volume 44:Number 3(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-22
• Subjects: asexual replication -- biological rhythm -- circadian -- fitness -- intra‐erythrocytic development cycle -- periodicity -- Plasmodium; Veterinary parasitology -- Immunological aspects -- Periodicals; Host-parasite relationships -- Immunological aspects -- Periodicals; 571.96
• DOI: 10.1111/pim.12898
• Languages: English
• ISSNs: 0141-9838

Abstract

Abstract: Aims: Malaria parasites exhibit daily rhythms in the intra‐erythrocytic development cycle (IDC) that underpins asexual replication in the blood. The IDC schedule is aligned with the timing of host feeding‐fasting rhythms. When the IDC schedule is perturbed to become mismatched to host rhythms, it readily reschedules but it is not known how. Methods: We intensively follow four groups of infections that have different temporal alignments between host rhythms and the IDC schedule for 10 days, before and after the peak in asexual densities. We compare how the duration, synchrony and timing of the IDC differs between parasites in control infections and those forced to reschedule by 12 hours and ask whether the density of parasites affects the rescheduling process. Results and conclusions: Our experiments reveal parasites shorten the IDC duration by 2–3 hours to become realigned to host feeding‐fasting rhythms with 5–6 days, in a density‐independent manner. Furthermore, parasites are able to reschedule without significant fitness costs for them or their hosts. Understanding the extent of, and limits on, plasticity in the IDC schedule may reveal targets for novel interventions, such as drugs to disrupt IDC regulation and preventing IDC dormancy conferring tolerance to existing drugs.