Case Series: Unbiased Deep Sequencing Analysis of Acute Infectious Conjunctivitis in an Ambulatory Eye Center in Berkeley, California. Issue 4 (April 2023)

• Record Type: Journal Article
• Authors: Kanai, Kuniyoshi; Whiteside, Meredith; Wong, Michael; La, Tammy; Nassiri, Maryam; Lee, Sam; Yeung, Sze Kei; Coulter, Adrienne; Roufail, Mareena; Ruder, Kevin; Chen, Cindi; Liu, David; Abraham, Thomas; Hinterwirth, Armin; Lietman, Thomas M.; Doan, Thuy; Seitzman, Gerami D.
• Other Names: Prajna Lalitha author non-byline.; Prajna N. Venkatesh author non-byline.; Gunasekaran Ramesh author non-byline.; Sharma Sankalp Singh author non-byline.; Teja Vishnu author non-byline.; Chaudhary Meenu author non-byline.; Sitaula Sanjeeta author non-byline.; Sié Ali author non-byline.; Coulibaly Boubacar author non-byline.; Bountogo Mamadou author non-byline.; Somkijrungroj Thanapong author non-byline.; Satitpitakul Vannarut author non-byline.; Tran Huy author non-byline.; Mai Linh Hoàng author non-byline.; Xuân Thảo Hạ author non-byline.; Tran Yen author non-byline.; Urzua Cristhian A. author non-byline.; Vega Fabian author non-byline.; Salgado Felipe author non-byline.; Cuitino Loreto author non-byline.; Pérez Fernando Pérez author non-byline.; Martínez Jaime Macías author non-byline.; Lansingh Van Charles author non-byline.; Thanapaisal Sukhumal author non-byline.; Laovirojjanakul Wipada author non-byline.; McKie George author non-byline.; Chavez Kenia author non-byline.; Redd Travis author non-byline.; Chamberlain Winston author non-byline.; Cheng Angel author non-byline.; Tham Vivien author non-byline.; Sansanayudh Wiwan author non-byline.; Yakoura Abba Kaka Hajia author non-byline.; Amza Abdou author non-byline.; Souley Abdoul Salam Youssoufou author non-byline.; Diori Adam Nouhou author non-byline.; Nassirou Beido author non-byline.; Kadri Boubacar author non-byline.; Mariama Boubacar author non-byline.; Ibrahim Cissé Mamadou author non-byline.; Roufaye Lamyne Aboubacar author non-byline.; Boulhassane Ramatou author non-byline.; Ali Saley author non-byline.; Abdou Zakou author non-byline.; Goren Lee author non-byline.; Sella Ruti author non-byline.; Kelliher Clare author non-byline.; Green Laura author non-byline.; Ong Hon Shing author non-byline.; Mehta Jod author non-byline.; Liu Yu-Chi author non-byline.; Pinsky Benjamin A. author non-byline.; Hwang De-Kuang author non-byline.; Fan Nai-Wen author non-byline.; Chiong Hong Sheng author non-byline.; Lacorzana Javier author non-byline.; Cabrera-Aguas Maria author non-byline.; Watson Stephanie author non-byline.; Tsui Edmund author non-byline.; Ramirez Joana author non-byline.; Cherian Nina M. author non-byline.; Feit-Leichman Rachel author non-byline.; Hughes Reginald E. author non-byline.; Onclinx Tania author non-byline.; Yu Carol author non-byline.; McClean Esmeralda author non-byline.; Molina Iliana author non-byline.; Hinterwirth Armin author non-byline.; Chen Cindi author non-byline.; Yu Danny author non-byline.; Liu David author non-byline.; Lebas Elodie author non-byline.; Colby Emily author non-byline.; Seitzman Gerami author non-byline.; Ruder Kevin author non-byline.; Zhong Lina author non-byline.; Deiner Michael author non-byline.; Abraham Thomas author non-byline.; Lietman Thomas author non-byline.; Doan Thuy author non-byline.; Porco Travis author non-byline.; McLeod Stephen author non-byline.; Kanai Kuniyoshi author non-byline.; Whiteside Meredith author non-byline.; Yeh Steven author non-byline.; Fashina Tolulope author non-byline.; Chodosh James author non-byline.; Tarkap Bridgit author non-byline.; Garap Jambi N. author non-byline.; Mangot Magdalene author non-byline.; Amel Edwin author non-byline.; Taleo Fasihah author non-byline.; Kasso Johnson author non-byline.; Willie Kalbule author non-byline.; Nanu Madopule author non-byline.; Rymill Prudence author non-byline.; Solomon Anthony W. author non-byline.;
• Is Part Of: Optometry and vision science. Volume 100:Issue 4(2023)
• Page Start: 276
• Page End: 280
• Publication Date: 2023-04
• Subjects: Optometry -- Periodicals; Physiological optics -- Periodicals; Vision disorders -- Periodicals; 617.7505
• DOI: 10.1097/OPX.0000000000002010
• Languages: English
• ISSNs: 1040-5488

Abstract

Abstract : SIGNIFICANCE: Acute infectious conjunctivitis poses significant challenges to eye care providers. It can be highly transmissible, and because etiology is often presumed, correct treatment and management can be difficult. This study uses unbiased deep sequencing to identify causative pathogens of infectious conjunctivitis, potentially allowing for improved approaches to diagnosis and management. PURPOSES: This study aimed to identify associated pathogens of acute infectious conjunctivitis in a single ambulatory eye care center. CASE REPORTS: This study included patients who presented to the University of California Berkeley eye center with signs and symptoms suggestive of infectious conjunctivitis. From December 2021 to July 2021, samples were collected from seven subjects (ages ranging from 18 to 38). Deep sequencing identified associated pathogens in five of seven samples, including human adenovirus D, Haemophilus influenzae, Chlamydia trachomatis, and human coronavirus 229E. CONCLUSIONS: Unbiased deep sequencing identified some unexpected pathogens in subjects with acute infectious conjunctivitis. Human adenovirus D was recovered from only one patient in this series. Although all samples were obtained during the COVID-19 pandemic, only one case of human coronavirus 229E and no SARS-CoV-2 were identified.