Development of a core descriptor set for Crohn's anal fistula. (22nd December 2022)

• Record Type: Journal Article
• Other Names: Williams Kate M. investigator.; Lamidi Segun investigator.; Coe Peter O. investigator.; Bordeianou Liliana G. investigator.; Hart Ailsa L. investigator.; Hind Daniel investigator.; Lindsay James O. investigator.; Lobo Alan J. investigator.; Myrelid Pär investigator.; Raine Tim investigator.; Sebastian Shaji investigator.; Fearnhead Nicola S. investigator.; Lee Matthew J. investigator.; Adams Katie investigator.; Almer Sven investigator.; Ananthakrishnan Ashwin investigator.; Bethune Robert M. investigator.; Block Mattias investigator.; Brown Steven R. investigator.; Cirocco William C. investigator.; Cooney Rachel investigator.; Davies Justin investigator.; Atici Semra D. investigator.; Dhar Anjan investigator.; Din Shahida investigator.; Drobne David investigator.; Espin‐Basany Eloy investigator.; Evans Jonathan P. investigator.; Fleshner Phillip R. investigator.; Folkesson Joakim investigator.; Fraser Aileen investigator.; Graf Wilhelm investigator.; Hahnloser Dieter investigator.; Hager Jakob investigator.; Hancock Laura investigator.; Hanzel Jurij investigator.; Hargest Rachel investigator.; Hedin Charlotte R. H. investigator.; Hill James investigator.; Ihle Christof investigator.; Jongen Johannes investigator.; Kader Rawen investigator.; Karmiris Konstantinos investigator.; Katsanos Konstantinos H. investigator.; Keller Debby S. investigator.; Kopylov Uri investigator.; Koutrabakis Ioannis E. investigator.; Lamb Chris A. investigator.; Landerholm Kalle investigator.; Lee Grace C. investigator.; Litta Francesco investigator.; Limdi Jimmy K. investigator.; Lopes Emily W. investigator.; Madoff Robert D. investigator.; Martin Sean T. investigator.; Martin‐Perez Beatriz investigator.; Michalopoulos George investigator.; Millan Monica investigator.; Münch Andreas investigator.; Nakov Radislav investigator.; Noor Nurulamin M. investigator.; Oresland Tom investigator.; Paquette Ian M. investigator.; Pellino Gianluca investigator.; Perra Teresa investigator.; Porcu Alberto investigator.; Roslani April C. investigator.; Samaan M. A. investigator.; Sebepos‐Rogers G. M. investigator.; Segal Jontahan P. investigator.; de Silva Shanika investigator.; Söderholm Mattias investigator.; Spinelli Antonio investigator.; Speight Ally investigator.; Steinhagen Randolph M. investigator.; Stenström Pernilla investigator.; Tsimogiannis Konstantinos E. investigator.; Varma Mika G. investigator.; Verma Ajay M. investigator.; Verstockt Bram investigator.; Warden Claire investigator.; Yassin Nuha investigator.; Zawadzki Antoni investigator.; Carr Paula investigator.; Devlin Brian investigator.; Mannick Sameer investigator.; Avery Pearl investigator.; Gecse Krisztina B. investigator.; Goren Idan investigator.; Hellström Per M. investigator.; Kotze Paulo G. investigator.; McWhirter Derek investigator.; Naik Amar S. investigator.; Sammour Tarik investigator.; Selinger Christian P. investigator.; Stein Sharon L. investigator.; Torres Joanna investigator.; Wexner Steven D. investigator.; Younge Lisa C. investigator.;
• Is Part Of: Colorectal disease. Volume 25:Number 4(2023)
• Page Start: 695
• Page End: 706
• Publication Date: 2022-12-22
• Subjects: anal fistula -- consensus -- Crohn's disease -- methodology; Colon (Anatomy) -- Diseases -- Periodicals; Rectum -- Diseases -- Periodicals; 616.34
• DOI: 10.1111/codi.16440
• Languages: English
• ISSNs: 1462-8910

Abstract

Abstract: Aim: Crohn's anal fistula (CAF) is a complex condition, with no agreement on which patient characteristics should be routinely reported in studies. The aim of this study was to develop a core descriptor set of key patient characteristics for reporting in all CAF research. Method: Candidate descriptors were generated from published literature and stakeholder suggestions. Colorectal surgeons, gastroenterologists and specialist nurses in inflammatory bowel disease took part in three rounds of an international modified Delphi process using nine‐point Likert scales to rank the importance of descriptors. Feedback was provided between rounds to allow refinement of the next ratings. Patterns in descriptor voting were assessed using principal component analysis (PCA). Resulting PCA groups were used to organize items in rounds two and three. Consensus descriptors were submitted to a patient panel for feedback. Items meeting predetermined thresholds were included in the final set and ratified at the consensus meeting. Results: One hundred and thirty three respondents from 22 countries completed round one, of whom 67.0% completed round three. Ninety seven descriptors were rated across three rounds in 11 PCA‐based groups. Forty descriptors were shortlisted. The consensus meeting ratified a core descriptor set of 37 descriptors within six domains: fistula anatomy, current disease activity and phenotype, risk factors, medical interventions for CAF, surgical interventions for CAF, and patient symptoms and impact on quality of life. Conclusion: The core descriptor set proposed for all future CAF research reflects characteristics important to gastroenterologists and surgeons. This might aid transparent reporting in future studies.