Five New Phenolic Glycosides from Viburnum luzonicum. Issue 4 (19th April 2023)

• Record Type: Journal Article
• Authors: Chen, Jia; Zhao, Min; Zhou, Hongjuan; Tang, Yiyuan; Ji, Wei; Shao, Jianhua; Zhao, Chunjie; Zhao, Chunchao
• Is Part Of: Chemistry & biodiversity. Volume 20:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-04-19
• Subjects: Viburnum luzonicum -- branches -- phenolic glycoside -- α-amylase inhibition -- α-glucosidase inhibition; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202300246
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Viburnum luzonicum is widely distributed in China. Its branch extracts showed potential α ‐amylase and α ‐glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A−E (1 –5 ), were obtained by bioassay‐guided isolation coupled with HPLC‐QTOF‐MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α ‐amylase and α ‐glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α ‐amylase (IC50 =17.5 μM) and α ‐glucosidase (IC50 =13.6 μM). Abstract :