B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency. (1st February 2012)

• Record Type: Journal Article
• Authors: Lougaris, Vassilios; Baronio, Manuela; Vitali, Massimiliano; Tampella, Giacomo; Soresina, Annarosa; Badolato, Raffaele; Plebani, Alessandro
• Other Names: Manfredi A. A. Academic Editor.; Zouali M. Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2012(2012)
• Publication Date: 2012-02-01
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/2012/960219
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective in vitro responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9). Our data suggest that expression levels of a surface receptor, namely, CXCL16, correlate with B cell responses mediated by TLR9 in common variable immunodeficiency.