Multi‐Pathway Microenvironment Regulation for Atherosclerosis Therapy Based on Beta‐Cyclodextrin/L‐Arginine/Au Nanomotors with Dual‐Mode Propulsion. Issue 9 (16th December 2021)

• Record Type: Journal Article
• Authors: Wu, Ziyu; Wu, Rui; Li, Xiaoyun; Wang, Xingwen; Tang, Xueting; Tan, Kaiyuan; Wan, Mimi; Mao, Chun; Xu, Xingquan; Jiang, Huiming; Li, Jiawei; Zhou, Min; Shi, Dongquan
• Is Part Of: Small. Volume 18:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-16
• Subjects: atherosclerosis therapy -- multi‐pathway microenvironment regulation -- nanomotors -- near‐infrared light -- nitric oxide; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202104120
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Most of the current non‐pharmacological treatment strategies for atherosclerosis (AS) suffer from poor penetration into the plaque and only aim at a certain factor in its formation process, resulting in limited therapeutic effect. Herein, a kind of nanomotor with dual‐mode propulsion is constructed, which is sensitive to higher reactive oxygen species (ROS) at the AS site and near‐infrared (NIR) laser by the covalent binding and self‐assembly of β‐cyclodextrin (β‐CD) and L‐arginine (LA) with immobilization of Au nanoparticles. NIR laser irradiation can be used as a driving force and to ablate inflammatory macrophages through the photothermal effect. The nitric oxide (NO) released by the nanomotors can be used as another driving force and a therapeutic agent to promote endothelial repair in the plaque site. LA can eliminate ROS in the inflammatory site, and β‐CD can promote the removal of cholesterol from foam cells. In particular, the two driving modes of nanomotors synergistically promote their aggregation and penetration in the plaque. This kind of nanomotor can regulate the microenvironment of AS in multiple ways, including combination therapy for endothelial repair, lipid clearance, and reducing ROS, which is expected to become a potential non‐pharmacological strategy in the treatment of AS. Abstract : A kind of beta‐cyclodextrin/L‐arginine/Au nanomotor with near‐infrared and nitric oxide dual‐mode propulsion is proposed, which has the advantages complementarity with sustainable chemical propulsion and controlled physical propulsion, and aims to enhance the anti‐atherosclerotic effects of non‐pharmacological therapeutic agents by targeting penetration into the plaque and multi‐link regulation of the atherosclerotic microenvironment.