A pelvic mass 21 years after a Wilms tumour: late recurrence or new tumour?. Issue 2 (May 2023)

• Record Type: Journal Article
• Authors: Bonet, Xavier; Oderda, Marco; Campobasso, Davide; Hoepffner, Jean-Luc
• Is Part Of: Urologia journal. Volume 90:Issue 2(2023)
• Page Start: 430
• Page End: 433
• Publication Date: 2023-05
• Subjects: Wilms tumour -- prostate embryonal rhabdomyosarcoma -- radiotherapy-induced -- sarcoma; Urology -- Periodicals; 616.6005
• DOI: 10.1177/03915603211026103
• Languages: English
• ISSNs: 0391-5603

Abstract

Introduction: Late Wilms tumour (WT) recurrences are rare events with poorly understood pathogenesis. They could be induced by previous chemo- and radiotherapy regimens, which can also prompt a rhabdomyomatous differentiation. Prostatic embryonal rhabdomyosarcoma (PER) is an extremely rare disease in adults, with an aggressive behaviour and abysmal prognosis. Radio-induced PER have been described. Case description: We report the case of a 29 years old man, with a history of WT, diagnosed with a symptomatic prostatic mass. Blastemic elements were shown at the transrectal biopsy, suggesting the possibility of a late WT recurrence. After laparoscopic resection, an unexpected pathologic diagnosis was reached: PER. Conclusion: We retrace and analyse the diagnostic and therapeutic path of the case that represents a mixture of two different conditions which might be unrelated or intertwined in a causal relationship. Among the differential diagnosis of a prostatic mass, the possibility of a prostatic sarcoma should not be overlooked, in presence of blastemic elements, even in a patient with a WT history.