Large animal model of vein grafts intimal hyperplasia: A systematic review. (July 2023)

• Record Type: Journal Article
• Authors: Fashina, Oluwatomini; Abbasciano, Riccardo G; McQueen, Liam W; Ladak, Shameem; George, Sarah J; Suleiman, Sadeeh; Punjabi, Prakash P; Angelini, Gianni D; Zakkar, Mustafa
• Is Part Of: Perfusion. Volume 38:Number 5(2023)
• Page Start: 894
• Page End: 930
• Publication Date: 2023-07
• Subjects: intimal hyperplasia -- vein grafts disease -- (coronary artery bypass graft) CABG -- porcine -- large animals; Perfusion (Physiology) -- Periodicals; Blood -- Circulation, Artificial -- Periodicals; Heart -- Surgery -- Periodicals; Extracorporeal Circulation -- Periodicals; Perfusion -- Periodicals; Circulation extracorporelle -- Périodiques; Perfusion -- Périodiques; 617.41
• DOI: 10.1177/02676591221091200
• Languages: English
• ISSNs: 0267-6591

Abstract

Coronary artery bypass grafting remains the treatment of choice for a large cohort of patients with significant coronary disease. Despite the increased use of arterial grafts, the long saphenous vein remains the most commonly used conduit. Long-term graft patency continues to be the Achilles heel of saphenous vein grafts. This is due to the development of intimal hyperplasia, a chronic inflammatory disease that results in the narrowing and occlusion of a significant number of vein grafts. Research models for intimal hyperplasia are essential for a better understanding of pathophysiological processes of this condition. Large animal models resemble human anatomical structures and have been used as a surrogate to study disease development and prevention over the years. In this paper, we systematically review all published studies that utilized large animal models of vein graft disease with a focus on the type of model and any therapeutic intervention, specifically the use of external stents/mesh.