A pipeline analysis of advanced therapy medicinal products. Issue 5 (May 2023)

• Record Type: Journal Article
• Authors: Wilkins, Georgina C.; Lanyi, Katherine; Inskip, Alexander; Ogunbayo, Oladapo J.; Brhlikova, Petra; Craig, Dawn
• Is Part Of: Drug discovery today. Volume 28:Issue 5(2023)
• Publication Date: 2023-05
• Subjects: ATMP -- Innovative medicinal products -- Pipeline analysis; Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2023.103549
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: In March 2022 we ran a pipeline for advanced therapy medicinal products (ATMPs). 12 of these ATMPs were already marketed in the EU and UK. 482 unique ATMPs for various indications were identified in 583 clinical trials. These ATMPs have both similarities with and differences to currently marketed ATMPs. Abstract : Advanced therapy medicinal products (ATMPs) are innovative biological products categorised as either gene, somatic cell, tissue-engineered or combined therapies. As of March 2022, 12 ATMPs are marketed in the EU and UK. We identified 482 unique ATMPs within 616 technology records from the National Institute for Health and Care Research Innovation Observatory database, 4 of which are currently marketed. These 482 ATMPs were identified in 583 clinical trials. Of the 616 records, 57.1% were for gene therapies and 1.6% were for combined therapies. Records covered various indications, including 130 haematological malignancies and 60 genetic disorders. Marketing authorisation intelligence was included in 14% of records.