Catalytic utilization of converter gas – an industrial waste for the synthesis of pharmaceuticals. Issue 16 (31st March 2023)

• Record Type: Journal Article
• Authors: Runikhina, Sofiya A.; Afanasyev, Oleg I.; Kuchuk, Ekaterina A.; Perekalin, Dmitry S.; Jagadeesh, Rajenahally V.; Beller, Matthias; Chusov, Denis
• Is Part Of: Chemical science. Volume 14:Issue 16(2023)
• Page Start: 4346
• Page End: 4350
• Publication Date: 2023-03-31
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d3sc00257h
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : From waste to value. An efficient and convenient ruthenium-catalyzed reduction of aromatic nitro compounds using converter gas as a reducing agent to produce valuable pharmaceuticals has been developed. Abstract : Converter gas is a large scale waste product that is usually burned to carbon dioxide and contributes to the world emission of greenhouse gases. Herein we demonstrate that instead of burning the converter gas can be used as a reducing agent in organic reactions to produce valuable pharmaceuticals and agrochemicals. In particular, amide-based selected drug molecules have been synthesized by a reaction of aromatic nitro compounds and carboxylic acids in the presence of converter gas. In addition, we showed that this gas can also be conveniently utilized to carryout classical reductive amination reaction.