Copper-catalyzed [3+2] annulation of O-acyl ketoximes with 2-aryl malonates for the synthesis of 3-aryl-4-pyrrolin-2-ones. Issue 35 (11th April 2023)

• Record Type: Journal Article
• Authors: Song, Xiao-Qing; Qiang, Xiao-Qi; Hu, Zi-Jun; Lyu, Xinyu; Tan, Sheng; Yao, Changsheng; Sun, Yong-Qiang; Miao, Chun-Bao; Yang, Hai-Tao
• Is Part Of: Chemical communications. Volume 59:Issue 35(2023)
• Page Start: 5225
• Page End: 5228
• Publication Date: 2023-04-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d3cc00367a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A copper-catalyzed [3+2] annulation of O -acyl ketoximes with 2-aryl malonates for the concise synthesis of 3-aryl-4-pyrrolin-2-ones has been developed. Abstract : A copper-catalyzed [3+2] annulation of O -acyl ketoximes with 2-aryl malonates for the concise synthesis of 3-aryl-4-pyrrolin-2-ones has been developed. The advantage of this method lies in the use of O -acyl oximes as an internal oxidant to generate the nucleophilic enamines and electrophilic p -quinone methides concurrently. The subsequent nucleophilic addition undergoes selectively on the α-C of malonates.