A Dermal Phototoxicity Study Following Intravenous Infusion Administration of Ciprofloxacin Hydrochloride in the Novel Microminipigs. (January 2013)

• Record Type: Journal Article
• Authors: Yoshikawa, Tsuyoshi; Takahashi, Yoshihiro; Kawaguchi, Hiroaki; Utsunomiya, Shinji; Miura, Naoki; Izumi, Hiroyuki; Miyoshi, Noriaki; Tanimoto, Akihide
• Is Part Of: Toxicologic pathology. Volume 41:Number 1(2013)
• Page Start: 109
• Page End: 113
• Publication Date: 2013-01
• Subjects: ciprofloxacin hydrochloride -- dermal -- phototoxicity -- swine -- ultraviolet.; Pathology -- Periodicals; Toxicology -- Periodicals; Pathology; Toxicology; 615.9
• DOI: 10.1177/0192623312452489
• Languages: English
• ISSNs: 0192-6233

Abstract

The authors evaluated dermal phototoxicity using the world smallest minipig (MMPig: Microminipig). MMPigs were administered 100 mg/kg ciprofloxacin hydrochloride with an infusion pump. The dorsal area of each animal was irradiated with ultraviolet-A irradiation. The left dorsal skin was irradiated at intensities of 5, 10, 15, and 20 J/cm 2, and the right dorsal back skin was set as a nonirradiated site. Gross and histopathological examinations were conducted before irradiation and from 1 to 72 hr after irradiation. Initial changes in the skin were necrosis of the basal and/or prickle cell layer and cellular infiltration from 24 hr after irradiation. Vesicle formation observed from 48 hr after irradiation was considered similar to bullous eruptions, a known side effect of fluoroquinolones in humans. Therefore, the authors suggest that the MMPig may be a useful experimental animal model for dermal phototoxicity studies.