Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines. Issue 35 (11th April 2023)

• Record Type: Journal Article
• Authors: Gupta, Anish; Jandial, Tanvi; Karuppasamy, Muthu; Bhuvanesh, Nattamai; Nagarajan, Subbiah; Maheswari, C. Uma; Sridharan, Vellaisamy
• Is Part Of: Chemical communications. Volume 59:Issue 35(2023)
• Page Start: 5233
• Page End: 5236
• Publication Date: 2023-04-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d3cc01370g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A palladium-catalyzed, solvent-dependent, intramolecular oxypalladation-initiated chemodivergent approach was established for the synthesis of functionalized benzazepines and tetrahydroquinolines. Abstract : Palladium-catalyzed, solvent-dependent intramolecular oxypalladation-triggered domino sequences of internal alkynes bearing tethered nucleophilic carboxylic ester and electrophilic enone functionalities were developed for the chemodivergent synthesis of two completely distinct biologically significant complex molecules including isochromenone-fused benzazepines and isobenzofuranone-fused tetrahydroquinolines/chromanes in a single synthetic operation.