Applying Na/Co(ii) bimetallic partnerships to promote multiple Co–H exchanges in polyfluoroarenes. Issue 36 (14th April 2023) - Logallo, Alessandra
Abstract : Using a bimetallic base combining Na and Co(ii ) enables the regioselective sodium-mediated di-cobaltation of fluoroarenes as well as transforming the three C–F bonds of trifluorobenzene into C–N bonds via a cascade activation process. Abstract : Heterobimetallic base NaCo(HMDS)3 [HMDS = N(SiMe3 )2 ] enables regioselective di-cobaltation of activated polyfluoroarenes under mild reaction conditions. For 1, 3, 5-C6 H2 X3 (X= Cl, F), NaCo(HMDS)3 in excess at 80 °C impressively induces the collective cleavage of five bonds (two C–H and three C–X) of the substrates via a cascade activation process that cannot be replicated by LiCo(HMDS)3 or KCo(HMDS)3 .