Resting-state fMRI functional connectivity and clinical correlates in Afro-descendants with schizophrenia and bipolar disorder. (June 2023)

• Record Type: Journal Article
• Authors: Luna, Licia P.; Sousa, Marcia Beatriz; Passinho, Jhule S.; Nardi, Antônio E.; Oertel, Viola; Veras, André Barciela; Alves, Gilberto Sousa
• Is Part Of: Psychiatry research. Volume 331(2023)
• Publication Date: 2023-06
• Subjects: Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2023.111628
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: High standard methods including resting state functional resonance and clinical measurements. Study conducted in Latin America with individuals of indigenous and black ancestry. No Caucasian sample of schizophrenia or BD. Results pointed to a similar pattern of brain connectivity disfunction when compared to the evidence with Caucasian and Asiatic samples of schizophrenia and bipolar disorder. Abstract: Schizophrenia (SCZ) and bipolar disorder (BD) exhibited altered activation in several brain areas, including the prefrontal and temporal cortex; however, a less explored topic is how brain connectivity and functional disturbances occur in non-Caucasian samples of SCZ and BD. Individuals with SCZ (n=20), BD (n=21), and healthy controls (HC, n=21) from indigenous and African ethnicity were submitted to clinical screening and functional assessments. Mood, compulsive and psychotic symptoms were also correlated to network dysfunction in each group. Two distinct networks' subcomponents demonstrated significant lower global efficiency (GE) in SCZ versus HC, corresponding to left posterior dorsal attention and medial left ventral attention (VA) networks. Lower GE was found in BD versus controls in four subcomponents, including the left medial and right VA. Higher compulsion scores correlated in BD with lower GE in the left VA, whereas increased report of alcohol abuse was associated with higher GE in left default mode network. Although preliminary, differences in the activation of specific networks, notably the left hemisphere, in SCZ versus controls, and lower activation in VA areas, in BD versus controls. Results highlight default mode and salient network as relevant for the emotional processing of SCZ and BD of indigenous and black ethnicity. Abstract: schizophrenia, bipolar disorder, functional neuroimaging, ethnicity, default network