Serum IFN-γ and RNAemia temporal profiles as biomarkers of severe COVID-19 in solid organ transplant and immunocompetent patients. Issue 5 (May 2023)

• Record Type: Journal Article
• Authors: Salto-Alejandre, Sonsoles; Carretero-Ledesma, Marta; Camacho-Martínez, Pedro; Berastegui-Cabrera, Judith; Infante, Carmen; Rodríguez-Álvarez, Regino; Alba, Jorge; Pérez-Palacios, Patricia; García-Díaz, Emilio; Roca, Cristina; Praena, Julia; Blanco-Vidal, María José; Santibáñez, Sonia; Valverde-Ortiz, Rocío; Nieto-Arana, Javier; García-García, Concepción; Gutiérrez-Campos, David; Maldonado, Natalia; Bernal, Gabriel; Gómez-Bravo, Miguel Ángel; Sobrino, José Manuel; Aguilar-Guisado, Manuela; Álvarez-Marín, Rocío; Goikoetxea-Aguirre, Josune; Oteo, José Antonio; Palacios-Baena, Zaira R.; Pascual, Álvaro; Lepe, José Antonio; Rodríguez-Baño, Jesús; Cisneros, José Miguel; Pachón, Jerónimo; Sánchez-Céspedes, Javier; Cordero, Elisa;
• Is Part Of: Journal of infection. Volume 86:Issue 5(2023)
• Page Start: 529
• Page End: 533
• Publication Date: 2023-05
• Subjects: Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2023.01.019
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: Highlights should be submitted in a separate editable file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including spaces, per bullet point). SOT recipients vs. no SOT patients have more undetectable IFN-γ and RNAemia rates. Undetectable IFN-α rates are similar in SOT recipients and in no SOT patients. In the no SOT patients, RNAemia and mortality decreased after 10 days of disease. RNAemia is associated with unfavorable outcome in SOT recipients. RNAemia and undetectable IFN-γ are associated with mortality in no SOT patients.