Exercise and education vs intra-articular saline for knee osteoarthritis: a 1-year follow-up of a randomized trial. Issue 5 (May 2023)

• Record Type: Journal Article
• Authors: Henriksen, M.; Christensen, R.; Kristensen, L.E.; Bliddal, H.; Bartholdy, C.; Boesen, M.; Ellegaard, K.; Guldberg-Møller, J.; Hunter, D.J.; Altman, R.; Bandak, E.
• Is Part Of: Osteoarthritis and cartilage. Volume 31:Issue 5(2023)
• Page Start: 627
• Page End: 635
• Publication Date: 2023-05
• Subjects: Knee -- Osteoarthritis -- Exercise, education -- Open-label placebo -- Subgroup -- Long-term; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2022.12.011
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Objective: To assess the longer-term effect of the Good Life with osteoarthritis in Denmark (GLAD) exercise and education program relative to open-label placebo (OLP) on changes from baseline in core outcomes in individuals with knee osteoarthritis (OA). Methods: In this 1-year follow-up of an open-label, randomized trial, patients with symptomatic and radiographically confirmed knee OA were monitored after being randomized to either the 8-week GLAD program or OLP given as 4 intra-articular saline injections over 8 weeks. The primary outcome was the change from baseline in the Knee injury and Osteoarthritis Outcome Score questionnaire (KOOS) pain subscale after 1 year in the intention-to-treat population. Key secondary outcomes were the KOOS function and quality of life subscales, and Patients' Global Assessment of disease impact. Results: 206 adults were randomly assigned: 102 to GLAD and 104 to OLP, of which only 137 (63/74 GLAD/OLP) provided data at 1 year. At one year the mean changes in KOOS pain were 8.4 for GLAD and 7.0 for OLP (Difference: 1.5 points; 95% CI −2.6 to 5.5). There were no between-group differences in any of the secondary outcomes. Conclusions: In this 1-year follow-up of individuals with knee OA, the 8-week GLAD program and OLP both provided minor longer-term benefits with no group difference. These results require confirmation given the significant loss to follow-up. Trial registration number: NCT03843931 .