Using wrist-worn accelerometers to identify the impact of medicines with anticholinergic or sedative properties on sedentary time: A 12-month prospective analysis. (June 2023)

• Record Type: Journal Article
• Authors: Lim, Renly; Dumuid, Dorothea; Parfitt, Gaynor; Stanford, Tyson; Post, Dannielle; Bilton, Rebecca; Kalisch Ellett, Lisa M.; Pratt, Nicole; Roughead, Elizabeth E.
• Is Part Of: Maturitas. Volume 172(2023)
• Page Start: 9
• Page End: 14
• Publication Date: 2023-06
• Subjects: Adverse drug events -- Anticholinergics -- Digital health -- Frailty -- Nursing home -- Sedative effects; Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2023.03.006
• Languages: English
• ISSNs: 0378-5122

Abstract

Highlights: The effects of medicines on physical function have not been quantified. We studied the association between medicine changes and 24-hour activity composition. As sedative/anticholinergic load increased, sedentary time increased. Wearable accelerometry bands can be used to monitor the effects of medicines on physical function. Abstract: Introduction: Studies have shown that use of medicines with sedative or anticholinergic properties is associated with a decline in physical function; however, the effects have not been quantified, and it is not known how and which specific physical movements are affected. This prospective study quantified the impact of a change in sedative or anticholinergic load over time on 24-hour activity composition. Methods: This study used data collected from a randomised trial assessing an ongoing pharmacist service in residential aged care. The 24-hour activity composition of sleep, sedentary behaviour, light-intensity physical activity, and moderate to vigorous physical activity was derived from 24-hour accelerometry bands. Mixed effect linear models were used to regress the multivariate outcome of 24-hour activity composition on medication load at baseline and at 12 months. A fixed effect interaction between trial stage and medication load was included to test for differing sedative or anticholinergic load effects at the two trial stages. Results: Data for 183 and 85 participants were available at baseline and 12 months respectively. There was a statistically significant interaction between medication load and time point on the multivariate outcome of 24-hour activity composition (sedative F = 7.2, p < 0.001 and anticholinergic F = 3.2, p = 0.02). A sedative load increase from 2 to 4 over the 12-month period was associated with an average increase in daily sedentary behaviour by an estimated 24 min. Conclusion: As sedative or anticholinergic load increased, there was an increase in sedentary time. Our findings suggest wearable accelerometry bands are a possible tool for monitoring the effects on physical function of sedative and anticholinergic medicines. Trial registration: The ReMInDAR trial was registered on the Australian and New Zealand Trials Registry ACTRN12618000766213.