Cavitary lung lesions in a neonate: Potential manifestation of COVID‐19 related multisystem inflammatory syndrome. Issue 1 (29th October 2021)

• Record Type: Journal Article
• Authors: Bakhle, Anish; Sreekumar, Kavita; Baracho, Bonny; Sardessai, Sanjay; Silveira, Maria Piedade
• Is Part Of: Pediatric pulmonology. Volume 57:Issue 1(2022)
• Page Start: 311
• Page End: 314
• Publication Date: 2021-10-29
• Subjects: COVID‐19 -- multisystem inflammatory syndrome -- neonate -- pulmonary cavities -- thromboembolism; Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.25732
• Languages: English
• ISSNs: 8755-6863

Abstract

Abstract: Background: The hyperinflammatory state of multisystem inflammatory syndrome in children (MIS‐C) predisposes to thromboembolic complications. We report a neonate with multiple cavitary lesions in lung, which we suspect could be a manifestation of multisystem inflammatory syndrome in neonate (MIS‐N) following maternal COVID‐19 infection during pregnancy. Case Report: Eight‐day‐old neonate was referred with fever and fast breathing. Mother was positive for COVID‐19 in 29th week. COVID‐19 reverse‐transcription polymerase chain reaction was negative, however, antibodies were positive. He had increased leucocyte count, and elevated levels of C‐reactive protein (CRP), procalcitonin, ferritin, lactate dehydrogenase, and d ‐dimer along with bilateral reticulonodular opacities on chest radiograph and multiple nodules with evidence of cavitation in both lungs on chest tomography. All cultures were negative. A possible diagnosis of MIS was made. Infant was treated with intravenous immunoglobulin (IVIG) which he responded to with resolution of symptoms. Conclusion: Neonates exposed to COVID‐19 should be evaluated for thromboembolic complications and IVIG can be one of the treatment modalities.