Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance. Issue 14 (5th December 2020)

• Record Type: Journal Article
• Authors: Mohamed, Sara; Latagliata, Roberto; Limongi, Maria Zaira; Nigro, Stefania; Sangiorgi, Eleonora; Nanni, Mauro; Piccioni, Annalina; Campagna, Alessia; Spiriti, Maria Antonietta Aloe; Carmosino, Ida; Molica, Matteo; Mariggiò, Elena; Rosati, Serena; Colafigli, Gioia; Fazio, Francesca; Luca, Maria Lucia De; Benedittis, Daniela De; Scalzulli, Emilia; Breccia, Massimo; Mancini, Marco
• Is Part Of: Leukemia & lymphoma. Volume 61:Issue 14(2020)
• Page Start: 3476
• Page End: 3483
• Publication Date: 2020-12-05
• Subjects: Myelodysplastic syndromes -- karyotype -- chromosomal translocations -- prognosis; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2020.1811861
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Prognostic role of chromosomal translocations (CT) in myelodysplasia (MDS) was retrospectively analyzed in 77 patients from GROM-L registry. Forty (51.9%) balanced, 28 (36.4%) unbalanced and 9 (11.7%) concomitant balanced and unbalanced CT were identified. Five-year overall survival (OS) of the entire cohort was 34.5% (CI 95% 22.5−46.5). Five-year OS of patients with unbalanced CT was significantly shorter than that of patients carrying balanced CT [22.3% (CI 95% 4.0−40.6) vs 44.0% (CI 95% 26.7−61.3) ( p = 0.042)]. Five-year OS of patients with CT included in complex karyotype (CK) was significantly shorter than that of patients with isolated CT or CT with another abnormality [5.5% (CI 95% 0−15.7) vs 42.9% (CI 95% 21.3−64.5) and vs 4% (CI 95% 31.6−79.2) ( p < 0.001)]. Presence of CT in MDS characterizes a more aggressive outcome only when associated with CK.