Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat. (May 2023)

• Record Type: Journal Article
• Authors: Lin, Che-Wei; Lin, Chun-Hung; Hsu, Ya-Wen; Pan, Tzu-Ming; Lee, Chun-Lin
• Is Part Of: Journal of functional foods. Volume 104(2023)
• Publication Date: 2023-05
• Subjects: Red mold dioscorea -- Ankaflavin -- Monascin -- Metabolic disorder -- Glucose intolerance -- High-fat high-fructose diet -- Adipose dysfunction; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2023.105537
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Monascin and ankaflavin improved blood glucose regulation. Monascin performed antioxidant and hypolipidemic effects. Ankaflavin performed anti-inflammatory effect and hypolipidemic effects. Abstract: Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes induced by long-term high fat and high fructose diet (HFFD) remain unclear. In this study, RMD, MS, and AK were orally administered to HFFD-fed rats for 10 weeks. The result showed that orally administered MS, AK, and RMD were able to prevent the develop-ment. MS had a more potent effect on lowering blood glucose, fructosamine, and insulin resistance, and increasing hepatic glucose transporters-2, adipocyte glucose transporters-4, and hypoxia-inducible factor 1-α. AK had a greater effect on lowering blood lipid, adipose pad, and adipose inflammatory factors (interlukin-1β, tumor necrosis factor-α, and interlukin-6) levels. Therefore, the prevention of type 2 diabetes and metabolic disorders of RMD could be mainly attributed to the synergistic effect of MS and AK.