Brain Diffusion Tensor Imaging Findings in Hashimoto's Thyroiditis. Issue 1 (6th November 2020)

• Record Type: Journal Article
• Authors: Gultekin, Mehmet Ali; Cesme, Dilek Hacer; Karaman, Ozcan; Yurtsever, Ismail; Tasan, Ertugrul; Yilmaz, Temel Fatih; Alkan, Alpay
• Is Part Of: Journal of neuroimaging. Volume 31:Issue 1(2021)
• Page Start: 215
• Page End: 221
• Publication Date: 2020-11-06
• Subjects: Diffusion tensor imaging -- Hashimoto's thyroiditis -- fractional anisotropy -- mean diffusivity; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12804
• Languages: English
• ISSNs: 1051-2284

Abstract

ABSTRACT: BACKGROUND AND PURPOSE: Hashimoto's thyroiditis (HT) is a type of autoimmune thyroid disease. Diffusion tensor imaging (DTI) can evaluate microstructural brain involvement in various diseases. We aimed to investigate whether there were any DTI differences in patients with HT, and the relationship between DTI values and disease duration time and thyroid peroxidase antibodies (TPOAb) levels. METHODS: We prospectively included 36 patients with HT (mean age 41.6 ± 13.8 years, range 18‐64 years) and 18 age and sex‐matched healthy control subjects (mean age 41.6 ± 13.1 years, range 18‐63 years). All patients were euthyroid at the time of imaging. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values of 15 distinct neuroanatomical locations were measured and compared. RESULTS: FA values of the patients with HT were lower in cingulum, globus pallidus (GP), cerebellar white matter (CWM) than the control ( P = .019, .002, and <.001, respectively). MD values of the CWM in patients were higher than the control ( P = .008). AD values of patients with HT were lower in the cingulum, posterior limbs of the internal capsule, GP, and putamen ( P = .038, .038, .030, and .045, respectively). RD values of cingulum and CWM in HT were higher than controls ( P <.001 and P = .011, respectively). There was a negative relationship between the FA values of PLIC and a positive relationship between the MD values of the corona radiata and TPOAb levels were detected. CONCLUSIONS: The current DTI study presented microstructural changes in the neurocognitive‐related areas that may be related to accompanying neurological findings in HT.