Seasonal variations on endothelium‐dependent flow‐mediated vasodilation in adults with type 2 diabetes and nondiabetic adults with hypertension and/or dyslipidaemia who perform regular exercise. Issue 1 (6th July 2020)

• Record Type: Journal Article
• Authors: Honda, Hiroto; Igaki, Makoto; Komatsu, Motoaki; Tanaka, Shin‐ichiro
• Is Part Of: Endocrinology, diabetes & metabolism. Volume 4:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-06
• Subjects: exercise -- flow‐mediated vasodilation -- type 2 diabetes; Endocrinology -- Periodicals; Diabetes -- Periodicals; Metabolism -- Periodicals; 616.4
• DOI: 10.1002/edm2.168
• Languages: English
• ISSNs: 2398-9238

Abstract

Abstract: Introduction: Endothelium‐dependent flow‐mediated dilation (FMD) of the brachial artery often changes seasonally. We aimed to examine the association between the seasonal variation on FMD and regular exercise in adults with type 2 diabetes (T2D) and nondiabetic adults with hypertension and/or dyslipidaemia (non‐T2D). Methods: This retrospective study included 14 T2D and 17 non‐T2D adults, who started to perform moderate‐intensity aerobic exercise for 30‐40 min/d at a hospital gym in 2006‐2010 and maintained exercise performance at least 2 d/wk until the end of the observation period. We observed and analysed the data for 5 years (from March 2011 to February 2016). FMD, cardio‐ankle vascular index (CAVI) and metabolic outcomes were compared among seasons in the T2D and non‐T2D groups. Results: The FMD values were lower in winter than in other seasons in both groups (all P < .01). The annual range of FMD was larger by 31% in the T2D group than in the non‐T2D group ( P < .05). The systolic blood pressure (BP) values were higher in winter than in other seasons in both groups (all P < .01), and the diastolic BP values were higher in winter than in summer in both groups (T2D: P < .05; non‐T2D: P < .01). CAVI and other outcomes did not change seasonally. Conclusions: Flow‐mediated vasodilation showed seasonal variation in T2D adults, even if they performed exercise regularly for a long period of time. Additionally, we found that the annual range of FMD might increase with the presence of T2D. Abstract : Flow‐mediated vasodilation (FMD) seasonally varies in adults with type 2 diabetes and nondiabetic adults with hypertension and/or dyslipidaemia despite performing long‐term exercises. Annual range of FMD may increase with the presence of type 2 diabetes.