A case of immunotactoid glomerulopathy in a patient with monoclonal gammopathy of renal significance. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Campdesuner, Victoria; Teklie, Yeshanew; Lattanzio, Natalia; Lorenzo, Christian; Bell, Stephen; Rodriguez, Yorlenis; Sastry, Ashok
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 11:Issue 1(2021)
• Page Start: 60
• Page End: 64
• Publication Date: 2021-01-02
• Subjects: Monoclonal gammopathy of renal significance -- immunotactoid glomerulopathy; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2020.1831744
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Monoclonal gammopathy of renal significance is a relatively new diagnosis that attributes kidney disease to damage caused by a monoclonal protein. There is growing recognition of this disease in patients previously diagnosed with monoclonal gammopathy of undetermined significance, as they increasingly develop clinically significant renal impairment requiring treatment. We outline a case of a patient presenting with worsening renal function, found to have a circulating monoclonal protein and ultimately diagnosed with a subtype of monoclonal gammopathy of renal significance referred to as immunotactoid glomerulopathy. Abbreviations: MGUS: Monoclonal gammopathy of undetermined significance; M-protein: Monoclonal protein; MM: Multiple myeloma; MGRS: Monoclonal gammopathy of renal significance; MGCS: Monoclonal gammopathy of clinical significance; CKD: Chronic kidney disease; C3 and C4: Complement 3 and complement 4, respectively; EF: Ejection fraction; CT: Computed tomography; IgG: Immunoglobulin G; GFR: Glomerular filtration rate; PET: Positron emission tomography; MRI: Magnetic Resonance Imaging.