Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide. (May 2023)
- Record Type:
- Journal Article
- Title:
- Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide. (May 2023)
- Main Title:
- Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide
- Authors:
- Ceña-Diez, Rafael
Spetz, Anna-Lena
Sönnerborg, Anders - Abstract:
- Abstract: The novel dipeptide WG-am and single-stranded oligonucleotide combination (WG-am:ssON) showed synergistic antiviral activity against HIV-1 integrase-, protease- or reverse transcriptase drug resistant isolates, with over 95% reduction. The highest selectivity indexes were for integrase resistant isolates. WG-am:ssON can be a future option for treatment of HIV drug-resistant strains.
- Is Part Of:
- Drug resistance updates. Volume 68(2023)
- Journal:
- Drug resistance updates
- Issue:
- Volume 68(2023)
- Issue Display:
- Volume 68, Issue 2023 (2023)
- Year:
- 2023
- Volume:
- 68
- Issue:
- 2023
- Issue Sort Value:
- 2023-0068-2023-0000
- Page Start:
- Page End:
- Publication Date:
- 2023-05
- Subjects:
- Dipeptide -- SsON -- Combination -- Synergy -- HIV -- Drug resistance -- INSTI
Drug resistance in cancer cells -- Periodicals
Cancer -- Chemotherapy -- Periodicals
616.994061 - Journal URLs:
- http://www.sciencedirect.com/science/journal/13687646 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.drup.2023.100955 ↗
- Languages:
- English
- ISSNs:
- 1368-7646
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3629.390500
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 27043.xml