Pretomanid-resistant tuberculosis. Issue 5 (May 2023)

• Record Type: Journal Article
• Authors: Koehler, Niklas; Andres, Sönke; Merker, Matthias; Dreyer, Viola; John, Agnieszka; Kuhns, Martin; Krieger, David; Choong, Eva; Verougstraete, Nick; zur Wiesch, Pia Abel; Wicha, Sebastian G.; König, Christina; Kalsdorf, Barbara; Sanchez Carballo, Patricia M.; Schaub, Dagmar; Werngren, Jim; Schön, Thomas; Peloquin, Charles A.; Schönfeld, Nicolas; Verstraete, Alain G.; Decosterd, Laurent A.; Aarnoutse, Rob; Niemann, Stefan; Maurer, Florian P.; Lange, Christoph
• Is Part Of: Journal of infection. Volume 86:Issue 5(2023)
• Page Start: 520
• Page End: 524
• Publication Date: 2023-05
• Subjects: Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2023.01.039
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: Moxifloxacin daily doses of 2400 mg were tolerated over several months. M. tuberculosis drug resistance could be overcome by a high-dose treatment regimen. No occurrence of cardiac AEs despite high doses of QTc interval prolonging drugs. No eradication of M. tuberculosis despite longstanding culture conversion. Development of pretomanid resistance on an insufficient treatment regimen.