Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D. (May 2023)

• Record Type: Journal Article
• Authors: Soltwedel, Johannes; Suckert, Theresa; Beyreuther, Elke; Schneider, Moritz; Boucsein, Marc; Bodenstein, Elisabeth; Nexhipi, Sindi; Stolz-Kieslich, Liane; Krause, Mechthild; von Neubeck, Cläre; Haase, Robert; Lühr, Armin; Dietrich, Antje
• Is Part Of: Radiotherapy and oncology. Volume 182(2023)
• Publication Date: 2023-05
• Subjects: Proton therapy -- Radiation-induced brain injury -- Preclinical mouse brain irradiation -- Normal tissue toxicity -- Open Data -- Multimodal Imaging; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2023.109591
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: Unique open dataset with multi-modal imaging of proton irradiated mouse brains. Provided data: Cone-beam computed tomography (CBCT) with dose and linear energy transfer (LET) simulations, brain atlas, longitudinal magnetic resonance imaging (MRI), brain atlas, and comprehensive tissue histology of whole mouse brains after proton irradiation of brain subvolumes. All data are spatially registered to the CBCT. Correlation of clinical, biological, and physical endpoints on single-cell level. Dataset accessible under https://doi.org/10.14278/rodare.557 . Abstract: Comprehending cellular changes of radiation-induced brain injury is crucial to prevent and treat the pathology. We provide a unique open dataset of proton-irradiated mouse brains consisting of medical imaging, radiation dose simulations, and large-scale microscopy images, all registered into a common coordinate system. This allows dose-dependent analyses on single-cell level.