Clinical factors predictive of new-onset seizure in patients with AIDS-related brain parenchymal lesion. (April 2023)

• Record Type: Journal Article
• Authors: Liang, Bo; Liang, Tingyu; Yang, Siyuan; Li, Jingjing; Gao, Haili; Ding, Xinghuan; Zhou, Xingang; Zhao, Hongxin; Feng, Enshan
• Is Part Of: Seizure. Volume 107(2023)
• Page Start: 4
• Page End: 12
• Publication Date: 2023-04
• Subjects: Seizure -- Risk factor -- Clinical characteristic -- AIDS -- Brain parenchymal lesion; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2023.02.021
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: We analyzed 222 AIDS-related brain parenchymal lesion patients' characteristics. Tuberculoma, cortex involvement, lesions in parietal lobe predict higher incidence of seizures. Lesions in periventricular area predict lower incidence of seizures. Multiple lesions significantly associated with focal to bilateral tonic-clonic seizures. 5. Lesions in temporal lobe significantly associated with focal impaired awareness seizure. Abstract: Purpose: This study aimed to determine the clinical characteristics and risk factors of new-onset seizure in patients with AIDS-related brain parenchymal lesion. Methods: A retrospective case-control study from January 2015 to December 2021 was conducted to determine the clinical characteristics and etiology of seizures in patients with AIDS-related brain parenchymal lesion. Univariate and multivariate logistic regression analyses were used to identify risk factors associated with seizures. Receiver operating characteristic (ROC) curve was used to analyze seizure prediction efficiency. Results: Among a total of 343 patients with AIDS-related brain lesions, 222 had brain parenchymal lesions. Of the 222 patients in the series (range: 16–81 y), 69 reported an episode of at least one seizure. A logistic regression analysis showed that tuberculoma, cortex involvement, and lesions in parietal lobe were found to have a strong association with higher incidence of seizures, whereas lesions in the periventricular area was less prone to seizure. The area under the ROC curve of these factors was 0.733, indicating these factors could predict seizure effectively. Amongst the 69 patients with seizures in multivariate analysis using logistic regression, multiple lesions significantly associated with focal to bilateral tonic-clonic seizures, and lesions in temporal lobe independently associated with focal impaired awareness seizure. Conclusions: Our study identified the underlying predictors between seizures and the clinical characteristics in a large population of patients with AIDS-related brain parenchymal lesions. These findings would provide further insights into developing effective prevention and treatment strategies aimed at improving the quality of life in the HIV population.