Electrochemistry of 5F-MDMB-PICA synthetic cannabinoid using a boron-doped diamond electrode with short anodic-cathodic pretreatment: A simple screening method for application in forensic analysis. (20th June 2023)

• Record Type: Journal Article
• Authors: Araújo, Daniel S.; Arantes, Luciano C.; Faria, Lucas V.; Souza, Karla A.O.; Pimentel, Dilton M.; Barbosa, Sandro L.; Richter, Eduardo M.; Muñoz, Rodrigo A.A.; dos Santos, Wallans T.P.
• Is Part Of: Electrochimica acta. Volume 454(2023)
• Publication Date: 2023-06-20
• Subjects: Adsorptive stripping voltammetry -- Drugs of abuse -- Electroanalysis -- New psychoactive substances -- On-site analysis; Electrochemistry -- Periodicals; Electrochemistry, Industrial -- Periodicals; 541.37
• DOI: 10.1016/j.electacta.2023.142356
• Languages: English
• ISSNs: 0013-4686

Abstract

Abstract: This work presents, for the first time, the electrochemical detection of methyl(2S)-2-{[1-(5-fluoropentyl)-1H-indole-3-carbonyl]amino}-3, 3-dimethyl butanoate (5F-MDMB-PICA), which is one of the most reported synthetic cannabinoids (SCs) in seized forensic samples. The 5F-MDMB-PICA detection is based on adsorptive stripping differential pulse voltammetry (AdSDPV) using a boron-doped diamond electrode (BDDE) with short anodic-cathodic pretreatment. This SC exhibited an irreversible oxidation process at around +1.2 V on a BDDE ( vs. Ag|AgCl|KCl(sat.) ) in 0.1 mol L −1 H2 SO4 . The proposed method presents a wide linear range (1.0 to 100 µmol L −1 ) for 5-MDMB-PICA determination and a low limit of detection (0.09 µmol L −1 ). The selectivity for 5F-MDMB-PICA detection at the BDDE using AdSDPV was evaluated using six other SCs and no interference was observed. In addition, the BDDE showed a good stability of 5F-MDMB-PICA electrochemical responses. Addition-recovery studies in real seized samples presented results close to 100%. Therefore, the combination of BDDE with AdSDPV demonstrates a great potential for a simple and fast screening of 5F-MDMB-PICA and an on-site application in forensic analysis. Graphical abstract: Image, graphical abstract