In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase Inhibitors (Adv. Therap. 4/2023). Issue 4 (13th April 2023)

• Record Type: Journal Article
• Authors: Braun, Sebastian; Paskas, Svetlana; Laube, Markus; George, Sven; Hofmann, Bettina; Lönnecke, Peter; Steinhilber, Dieter; Pietzsch, Jens; Mijatović, Sanja S.; Maksimović‐Ivanić, Danijela; Hey‐Hawkins, Evamarie
• Is Part Of: Advanced therapeutics. Volume 6:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-04-13
• Subjects: Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202370011
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract : Cyclooxygenase‐2 (COX‐2) and 5‐lipoxygenase (5‐LO) are key enzymes in the biosynthesis of pro‐inflammatory and tumor‐inducing eicosanoids. Thus, dual COX‐2/5‐LO inhibition may represent a promising strategy to prevent the pathogenesis of cancer and for cancer treatment. The bioisosteric replacement of the fluorophenyl moiety in RWJ‐63556 by meta ‐ or para ‐carborane results in potent derivatives showing dual COX‐2/5‐LO inhibitory and antitumor activity. This is reported by Evamarie Hey‐Hawkins and co‐workers in article number 2200252 .