A pH‐responsive Zr‐based metal organic framework PCN‐777 as a potential oral drug carrier. Issue 8 (2nd March 2023)

• Record Type: Journal Article
• Authors: He, Qing; Lu, Wenwen; Jiang, Xiaoying; Han, Yuanbo; Yu, Hongliu; Zhao, Hong; Guan, Xinghua; Lin, Wenxin
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 649:Issue 8(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-02
• Subjects: PCN-777 -- Metal-organic framework -- pH-responsive -- Oral drug carrier -- Biocompatibility; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.202200323
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract: A Zr‐based metal‐organic framework PCN‐777 with good biocompatibility was synthesized by solvothermal method using 2, 4, 6‐Tris(4‐Carboxyphenyl)‐1, 3, 5‐Triazine and ZrOCl2 ⋅ 8H2 O as raw materials. Its structure was identified and the results showed that it had good crystallinity. Then the anti‐inflammatory drug ibuprofen sodium was loaded into PCN‐777 to establish an IBUNa@PCN‐777 compound and the maximum loading capacity was tested. When the mass ratio of IBUNa to PCN‐777 was 4 : 1, the loading of IBUNa in IBUNa@PCN‐777 reached the maximum value 72.53 wt %. Biocompatibility investigation indicated PCN‐777 and IBUNa@PCN‐777 had good biocompatibility. Moreover, the drug release behavior of IBUNa@PCN‐777 testified the drug release at pH 7.4(>80 %) was greater than that at pH 2.0(<20 %). indicated that IBUNa@PCN‐777 had good pH response in simulated digestive environments. The above results demonstrated that PCN‐777 had potential application prospects as an oral drug carrier. Abstract :