Electrochemical Investigation on Kinetics of Xanthine Metabolism and Inhibition Effect of Febuxostat on Xanthine Oxidase Activity. Issue 4 (11th November 2022)

• Record Type: Journal Article
• Authors: Liu, Fuxin; Shang, Tianyi; Han, Lingling; He, Nan; Liu, Xiuhui
• Is Part Of: Electroanalysis. Volume 35:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-11
• Subjects: Xanthine metabolism -- Electrochemical method -- Febuxostat -- Xanthine oxidase -- Inhibition effect; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202200403
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: Xanthine is a significant biomolecule and its concentration level in urine and blood plasma is an indicator of specified pathological states. Here, a new sensing platform was designed, which showed excellent analytical performance for xanthine. Importantly, it is the first time to investigate the kinetics of xanthine metabolic reaction by electrochemical method. The results demonstrated that the conversion of xanthine to uric acid completely conformed to the Michaelis‐Menten kinetics. Furthermore, we also studied the inhibitory effect of febuxostat on xanthine oxidase activity detailed. As expected, the work may offer potential value for researchers in the treatment of hyperuricemia and gout. Abstract :