Thermosensation involving thermo-TRPs. (15th January 2021)

• Record Type: Journal Article
• Authors: Kashio, Makiko
• Is Part Of: Molecular and cellular endocrinology. Volume 520(2021)
• Publication Date: 2021-01-15
• Subjects: TRP channel -- Thermosensation -- Body temperature; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2020.111089
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: The transient receptor potential (TRP) channels constitute a superfamily of large ion channels that are activated by a wide range of chemical, mechanical and thermal stimuli. TRP channels with temperature sensitivity are called thermo-TRPs. They are involved in diverse physiological functions through their detection of external environmental temperature and internal body temperature. Each thermo-TRP has its own characteristic temperature threshold for activation. As a group, they cover temperatures ranging from cold to nociceptive high temperatures. Recently, many studies have identified the functions of thermo-TRPs residing in deep organs where they are exposed to body temperature. Importantly, temperature thresholds of thermo-TRPs can be regulated by physiological factors enabling their function at relatively constant body temperature. Moreover, several thermo-TRPs are reportedly engaged in body temperature regulation. This review will summarize the current understanding of thermo-TRPs, including their roles in thermosensation and functional regulation of physiological responses at body temperature and the regulation of body temperature. Highlights: Current understanding of temperature-sensitive transient receptor potential channels (thermo-TRPs). Collaborative involvement of thermo-TRPs in somatosensory system to cover wide range of temperature. Physiological significance of internal body temperature sensing by thermo-TRPs.