Adipose tissue metabolic changes in chronic kidney disease. Issue 2 (27th April 2023)

• Record Type: Journal Article
• Authors: Serrano, Eurico; Shenoy, Prashamsa; Martinez Cantarin, Maria Paula
• Is Part Of: Immunometabolism. Volume 5:Issue 2(2023)
• Page Start: e00023
• Publication Date: 2023-04-27
• Subjects: chronic kidney disease -- adipose tissue inflammation -- adipokines -- chronic inflammation -- protein energy wasting -- insulin resistance -- adiponectin -- leptin; 616.079
• DOI: 10.1097/IN9.0000000000000023
• Languages: English
• ISSNs: 2633-0407

Abstract

Abstract : Adipose tissue is a complex organ whose functions go beyond being an energy reservoir to sustain proper body energy homeostasis. Functioning as an endocrine organ, the adipose tissue has an active role in the body's metabolic balance regulation through several secreted factors generally termed as adipokines. Thus, adipose tissue dysregulation in chronic kidney disease (CKD) can have a deep impact in the pathophysiology of diseases associated with metabolic dysregulation including metabolic syndrome, insulin resistance (IR), atherosclerosis, and even cachexia. CKD is a progressive disorder linked to increased morbidity and mortality. Despite being characterized by renal function loss, CKD is accompanied by metabolic disturbances such as dyslipidemia, protein energy wasting, chronic low-grade inflammation, IR, and lipid redistribution. Thus far, the mechanisms by which these changes occur and the role of adipose tissue in CKD development and progression are unclear. Further understanding of how these factors develop could have implications for the management of CKD by helping identify pharmacological targets to improve CKD outcomes.