Ceria Nanoparticles as Copper Chaperones that Activate SOD1 for Synergistic Antioxidant Therapy to Treat Ischemic Vascular Diseases. Issue 16 (10th March 2023)

• Record Type: Journal Article
• Authors: Im, Gwang‐Bum; Kim, Young Geon; Yoo, Tae Yong; Kim, Yeong Hwan; Kim, Kang; Hyun, Jiyu; Soh, Min; Hyeon, Taeghwan; Bhang, Suk Ho
• Is Part Of: Advanced materials. Volume 35:Issue 16(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-10
• Subjects: anti‐inflammation -- antioxidants -- nanozymes -- oxidative stress -- superoxide dismutase 1; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202208989
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: All exogenous nanomaterials undergo rapid biotransformation once injected into the body and fall short of executing the intended purpose. Here, it is reported that copper‐deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects over pristine ceria nanoparticles, as the released copper buffers the depletion of glutathione while providing the bioavailable copper as a cofactor for the antioxidant enzyme, superoxide dismutase 1. The upregulated intracellular antioxidants along with the ceria nanoparticles synergistically scavenge reactive oxygen species and promote anti‐inflammation and M2 polarization of macrophages by modulating signal transducer and activator of transcription 1 and 6 (STAT1 and STAT6). The therapeutic effect of CuCe NPs is demonstrated in ischemic vascular diseases (i.e., murine models of hindlimb ischemia and myocardial infarction) in which the copper‐deposition affords increased perfusion and alleviation in tissue damage. The results provide rationale that metal oxide nanomaterials can be designed in a way to induce the upregulation of specific biological factors for optimal therapeutic performance. Abstract : Ceria nanoparticles deposited with copper ions, cofactors for the indigenous antioxidant enzyme, superoxide dismutase 1 (SOD1), are synthesized for effective and synergistic antioxidant therapy to treat ischemic vascular diseases in which the imbalance of reactive oxygen species (ROS) aggravates the tissue damage. Ceria nanoparticles chaperone copper ions to elevate the expression of SOD1 to significantly reduce the ROS‐induced damage.