Cover Picture: The Rigid Core and Flexible Surface of Amyloid Fibrils Probed by Magic‐Angle‐Spinning NMR Spectroscopy of Aromatic Residues (Angew. Chem. Int. Ed. 19/2023). Issue 19 (30th March 2023)

• Record Type: Journal Article
• Authors: Becker, Lea Marie; Berbon, Mélanie; Vallet, Alicia; Grelard, Axelle; Morvan, Estelle; Bardiaux, Benjamin; Lichtenecker, Roman; Ernst, Matthias; Loquet, Antoine; Schanda, Paul
• Is Part Of: Angewandte Chemie international edition. Volume 62:Issue 19(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-30
• Subjects: Aromatic Side Chains -- Isotopic Labeling -- Protein Dynamics -- Ring Flips -- Spin Relaxation; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202304138
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Rock‐solid amyloid? . Aromatic residues in the core of the amyloid fibrils HELLF and HET‐s show no sign of ring flips suggesting a rigid core that does not undergo "breathing motions". Aromatic residues facing outside on the other hand are highly flexible and show ring flips on various timescales. These conclusions could be drawn from dynamics measurements by solid‐state MAS NMR in combination with specific labeling of phenylalanines and tyrosines as Paul Schanda et al. describe in their Research Article (e202219314 ).