Water Activation for Boosting Electrochemiluminescence. (30th March 2023)

• Record Type: Journal Article
• Authors: Xi, Mengzhen; Wu, Zhichao; Luo, Zhen; Ling, Ling; Xu, Weiqing; Xiao, Runshi; Wang, Hengjia; Fang, Qie; Hu, Liuyong; Gu, Wenling; Zhu, Chengzhou
• Is Part Of: Angewandte Chemie. Volume 135:Number 19(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-30
• Subjects: Biosensors -- Electrochemiluminescence -- Luminol -- Transition-Metal Layered Double Hydroxides -- Water Oxidation Catalysts; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202302166
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: In conventional luminol electrochemiluminescence (ECL) systems, hydrogen peroxide and dissolved oxygen are employed as typical co‐reactants to produce reactive oxygen species (ROS) for efficient ECL emission. However, the self‐decomposition of hydrogen peroxide and limited solubility of oxygen in water inevitably restrict the detection accuracy and luminous efficiency of luminol ECL system. Inspired by ROS‐mediated ECL mechanism, for the first time, we used cobalt‐iron layered double hydroxide as co‐reaction accelerator to efficiently activate water to generate ROS for enhancing luminol emission. Experimental investigations verify the formation of hydroxyl and superoxide radicals in the process of electrochemical water oxidation, which subsequently react with luminol anion radicals to trigger strong ECL signals. Finally, the detection of alkaline phosphatase has been successfully achieved with impressive sensitivity and reproducibility for practical sample analysis. Abstract : Water is demonstrated as an innovative co‐reactant in the luminol electrochemiluminescence system for the first time. Cobalt‐iron layered double hydroxide serves as an advanced co‐reaction accelerator to efficiently catalyze the oxidation of water for the generation of reactive oxygen species, achieving the enhancement of electrochemiluminescence emission for sensitive biosensing.