Atomic‐Level Regulation of Cobalt Single‐Atom Nanozymes: Engineering High‐Efficiency Catalase Mimics. (24th March 2023)

• Record Type: Journal Article
• Authors: Chen, Yuanjun; Jiang, Bing; Hao, Haigang; Li, Haijing; Qiu, Chenyue; Liang, Xiao; Qu, Qingyun; Zhang, Zedong; Gao, Rui; Duan, Demin; Ji, Shufang; Wang, Dingsheng; Liang, Minmin
• Is Part Of: Angewandte Chemie. Volume 135:Number 19(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-24
• Subjects: Atomic-Level Regulation -- Catalase Mimics -- Co Single-Atom -- Nanozymes; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202301879
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Nanozymes aim to mimic the highly evolved active centers of natural enzymes. Despite progress in nanozyme engineering, their catalytic performance is much less favorable compared with natural enzymes. This study shows that precise control over the atomic configuration of the active centers of Co single‐atom nanozymes (SAzymes) enables the rational regulation of their catalase‐like performance guided by theorical calculations. The constructed Co‐N3 PS SAzyme exhibits an excellent catalase‐like activity and kinetics, exceeding the representative controls of Co‐based SAzymes with different atomic configurations. Moreover, we developed an ordered structure‐oriented coordination design strategy for rationally engineering SAzymes and established a correlation between the structure and enzyme‐like performance. This work demonstrates that precise control over the active centers of SAzymes is an efficient strategy to mimic the highly evolved active sites of natural enzymes. Abstract : A correlation between the atomic structures of Co single‐atom nanozymes and their catalase‐like performance is established by both computational screening and experimental design. A strategy is elucidated for atomic‐level regulation of Co single‐atom nanozymes operating as catalase mimics.