Acoustic radiation force optical coherence elastography: A preliminary study on biomechanical properties of trabecular meshwork. Issue 5 (18th January 2023)

• Record Type: Journal Article
• Authors: Ai, Sizhu; Zhang, Yubao; Shi, Gang; Wang, Yidi; Liu, Guo; Han, Xiao; Zhao, Yanzhi; Yang, Hongwei; He, Xingdao
• Is Part Of: Journal of biophotonics. Volume 16:Issue 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-18
• Subjects: acoustic radiation force -- biomechanical properties -- optical coherence elastography -- optical coherence tomography -- trabecular meshwork; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.202200317
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: Evaluating biomechanical properties of trabecular meshwork (TM) is of great significance for understanding the mechanism of aqueous humor circulation and its relationship to some eye diseases such as glaucoma; however, there is almost no relevant study due to the lack of clinical measurement tool. In this paper, an acoustic radiation force optical coherence elastography (ARF‐OCE) system is developed with the advantages of noninvasive detection, high resolution, high sensitivity, and high‐speed imaging, by which elastic modulus of the porcine and human TMs is accurately quantified. As the first OCE imaging of TM, our study demonstrates that ARF‐OCE may be an effective approach to advance the research of diseases related to aqueous humor circulation. Abstract : In this preliminary study, for the first time the elasticity of the trabecular meshwork (TM) is quantified by using the optical coherence elastography (OCE) technique, where the feasibility and reliability are verified by porcine and human samples. With advantages of noninvasive detection, high resolution, high sensitivity, and real‐time imaging, OCE may be an efficient method for the measurement of TM elasticity, which may improve understanding, diagnosis, and treatment of many ocular disorders such as glaucoma.